Blockade of Cholecystokinin Type 2 Receptors Prevents the Onset of Vincristine-Induced Neuropathy in Mice

Blockade of Cholecystokinin Type 2 Receptors Prevents the Onset of Vincristine-Induced Neuropathy in Mice

Vincristine (VCR) is responsible for the onset of the VCR-induced peripheral neuropathy (VIPN), associated with neuropathic pain. Several reports have strongly linked the cholecystokinin type 2 receptor (CCK2R) to nociceptive modulation. Thus, our aim was to evaluate the effect of CCK2R blockade on...

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Bibliographic Details
Main Authors: Amandine Bernard, Aurore Danigo, Mohamad Mroué, Amandine Rovini, Laurence Richard, Angélique Nizou, Alexis Desmoulière, Franck Sturtz, Claire Demiot, Sylvie Bourthoumieu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
chemotherapy-induced peripheral neuropathy
vincristine
allodynia
proglumide
Ly225910
CCK2R
Online Access:https://www.mdpi.com/1999-4923/14/12/2823

Internet

https://www.mdpi.com/1999-4923/14/12/2823

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