Dampened Inflammatory Signalling and Myeloid-Derived Suppressor-Like Cell Accumulation Reduces Circulating Monocytic HLA-DR Density and May Associate With Malignancy Risk in Long-Term Renal Transplant Recipients

Dampened Inflammatory Signalling and Myeloid-Derived Suppressor-Like Cell Accumulation Reduces Circulating Monocytic HLA-DR Density and May Associate With Malignancy Risk in Long-Term Renal Transplant Recipients

BackgroundMalignancy is a major cause of morbidity and mortality in transplant recipients. Identification of those at highest risk could facilitate pre-emptive intervention such as reduction of immunosuppression. Reduced circulating monocytic HLA-DR density is a marker of immune depression in the ge...

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Bibliographic Details
Main Authors: Matthew J. Bottomley, Paul N. Harden, Kathryn J. Wood, Joanna Hester, Fadi Issa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
monocyte
kidney transplantation
immunosuppression
HLA-DR
malignancy
long term
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.901273/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.901273/full

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