Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

Rho-family GTPase Rac1 activates the WAVE complex (WRC) to promote Arp2/3-mediated actin assembly in various processes. Here, the authors determined cryo-EM structures of WRC bound to Rac1 in different states, revealing how Rac1 binding activates WRC.

Bibliographic Details
Main Authors: Bojian Ding, Sheng Yang, Matthias Schaks, Yijun Liu, Abbigale J. Brown, Klemens Rottner, Saikat Chowdhury, Baoyu Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33174-3

Internet

https://doi.org/10.1038/s41467-022-33174-3

Similar Items