Effect of Selected Silyl Groups on the Anticancer Activity of 3,4-Dibromo-5-Hydroxy-Furan-2(5<i>H</i>)-One Derivatives

Effect of Selected Silyl Groups on the Anticancer Activity of 3,4-Dibromo-5-Hydroxy-Furan-2(5<i>H</i>)-One Derivatives

The pharmacological effects of carbon to silicon bioisosteric replacements have been widely explored in drug design and medicinal chemistry. Here, we present a systematic investigation of the impact of different silyl groups on the anticancer activity of mucobromic acid (MBA) bearing furan-2(<i&g...

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Bibliographic Details
Main Authors: Radoslaw Kitel, Anna Byczek-Wyrostek, Katarzyna Hopko, Anna Kasprzycka, Krzysztof Walczak
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
antiproliferative activity
apoptosis
furan-2(5<i>H</i>)-one
bioisosteres
silyl ethers
Online Access:https://www.mdpi.com/1424-8247/14/11/1079

Internet

https://www.mdpi.com/1424-8247/14/11/1079

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