Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts. They play essential roles in the outcome of...

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Bibliographic Details
Main Authors: Philippe Holzmuller, Anne Geiger, Romaric Nzoumbou-Boko, Joana Pissarra, Sarra Hamrouni, Valérie Rodrigues, Frédéric-Antoine Dauchy, Jean-Loup Lemesre, Philippe Vincendeau, Rachel Bras-Gonçalves
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
macrophage activation
l-arginine metabolism
arginase
secretome
trypanosomatids
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00778/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00778/full

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