Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection.

Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection.

Loss of the conserved "cryptic" plasmid from C. trachomatis and C. muridarum is pleiotropic, resulting in reduced innate inflammatory activation via TLR2, glycogen accumulation and infectivity. The more genetically distant C. caviae GPIC is a natural pathogen of guinea pigs and induces upp...

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Bibliographic Details
Main Authors: Lauren C Frazer, Toni Darville, Kumar Chandra-Kuntal, Charles W Andrews, Matthew Zurenski, Margaret Mintus, Yasser M AbdelRahman, Robert J Belland, Robin R Ingalls, Catherine M O'Connell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3265510?pdf=render

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http://europepmc.org/articles/PMC3265510?pdf=render

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