DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

Summary: Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia virus (VACV) protein C16. Here, VACV protein C4 is...

Full description

Bibliographic Details
Main Authors: Simon R. Scutts, Stuart W. Ember, Hongwei Ren, Chao Ye, Christopher A. Lovejoy, Michela Mazzon, David L. Veyer, Rebecca P. Sumner, Geoffrey L. Smith
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316103

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718316103

Similar Items