The parallel tetrameric DNA G-quadruplex formed by the two-repeat C9orf72 GGGGCC sequence in solution

The parallel tetrameric DNA G-quadruplex formed by the two-repeat C9orf72 GGGGCC sequence in solution

The abnormal expansion of G-rich hexanucleotide repeat, GGGGCC (G4C2), in chromosome 9 open reading frame 72 (C9orf72) is known to be the prevailing genetic cause of two fatal degenerative neurological diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It is well known...

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Bibliographic Details
Main Authors: Changdong Liu, Bo Zhou, Naining Xu, Chun Po Fung, Bing Yan, Monica Ching Suen, Zeguo Huang, Guang Zhu
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2022-11-01
Series:Magnetic Resonance Letters
Subjects:
Hexanucleotide repeat G4C2 expansion
G-quadruplex
Amyotrophic lateral sclerosis (ALS)
Frontotemporal dementia (FTD)
Nuclear magnetic resonance (NMR)
Online Access:http://www.sciencedirect.com/science/article/pii/S2772516222000389

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http://www.sciencedirect.com/science/article/pii/S2772516222000389

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