Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice

Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice

Abstract Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer influences proliferation, metastas...

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Bibliographic Details
Main Authors: Mostafa A. Aboouf, Julia Armbruster, Franco Guscetti, Markus Thiersch, Andreas Boss, Axel Gödecke, Sandra Winning, Claudia Padberg, Joachim Fandrey, Glen Kristiansen, Anne Bicker, Thomas Hankeln, Max Gassmann, Thomas A. Gorr
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34614-w

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https://doi.org/10.1038/s41598-023-34614-w

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