The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains

The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains

Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in the brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers and plaques. Macroautophagy, a form of autophagy characteriz...

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Bibliographic Details
Main Authors: Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P. Ponce, Carol D. SanMartín, Diego Rojas-Rivera, Natalia Salvadores, Maria I. Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44203-6

Internet

https://doi.org/10.1038/s41598-023-44203-6

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