PIKFYVE inhibitors trigger interleukin‐24‐dependent cell death of autophagy‐dependent melanoma

PIKFYVE inhibitors trigger interleukin‐24‐dependent cell death of autophagy‐dependent melanoma

Inhibitors specifically targeting the 1‐phosphatidylinositol 3‐phosphate 5‐kinase (PIKFYVE) disrupt lysosome homeostasis, thereby selectively terminating autophagy‐dependent human cancer cells in vivo as well as in vitro without harming the viability of nonmalignant cells. To elucidate the mechanism...

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Bibliographic Details
Main Authors: Ajit Roy, Arup R. Chakraborty, Melvin L. DePamphilis
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Molecular Oncology
Subjects:
autophagy
endoplasmic‐reticulum‐stress
interleukin‐24
PIKFYVE
PIP4K2C
WX8
Online Access:https://doi.org/10.1002/1878-0261.13607

Internet

https://doi.org/10.1002/1878-0261.13607

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