HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model

HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model

Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are...

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Bibliographic Details
Main Authors: Min Cai, Yingbo Zhu, Mary Regis Shanley, Carole Morel, Stacy M. Ku, Hongxing Zhang, Yuan Shen, Allyson K. Friedman, Ming-Hu Han
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Neurobiology of Stress
Subjects:
HCN channel inhibitor
Ih current
Antidepressants
Ventral tegmental area
Major depressive disorder
Chronic social defeat stress model
Online Access:http://www.sciencedirect.com/science/article/pii/S235228952300053X

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http://www.sciencedirect.com/science/article/pii/S235228952300053X

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