De novo gene signature identification from single‐cell RNA‐seq with hierarchical Poisson factorization

De novo gene signature identification from single‐cell RNA‐seq with hierarchical Poisson factorization

Abstract Common approaches to gene signature discovery in single‐cell RNA‐sequencing (scRNA‐seq) depend upon predefined structures like clusters or pseudo‐temporal order, require prior normalization, or do not account for the sparsity of single‐cell data. We present single‐cell hierarchical Poisson...

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Bibliographic Details
Main Authors: Hanna Mendes Levitin, Jinzhou Yuan, Yim Ling Cheng, Francisco JR Ruiz, Erin C Bush, Jeffrey N Bruce, Peter Canoll, Antonio Iavarone, Anna Lasorella, David M Blei, Peter A Sims
Format: Article
Language:English
Published: Springer Nature 2019-02-01
Series:Molecular Systems Biology
Subjects:
dimensionality reduction
gene signature discovery
glioma
single‐cell RNA‐seq
Online Access:https://doi.org/10.15252/msb.20188557

Internet

https://doi.org/10.15252/msb.20188557

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