Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage

Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage

Brain-derived neurotrophic factor (BDNF) is a classic neuroprotective and pro-regenerative factor in peripheral and central nervous tissue. Its ability to stimulate the restoration of damaged nerve and brain tissue after ischemic stroke and intraventricular hemorrhage has been demonstrated. However,...

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Bibliographic Details
Main Authors: Stalik Dzhauari, Svetlana Litvinova, Anastasia Efimenko, Natalia Aleksandrushkina, Nataliya Basalova, Maxim Abakumov, Natalia Danilova, Pavel Malkov, Vadim Balabanyan, Tatiana Bezuglova, Viktor Balayants, Maxim Mnikhovich, Mikhail Gulyaev, Mariya Skryabina, Vladimir Popov, Dmitry Stambolsky, Tatiana Voronina, Vsevolod Tkachuk, Maxim Karagyaur
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
intracerebral hemorrhage
stroke
brain-derived neurotrophic factor
urokinase plasminogen activator
glutamate-induced neurotoxicity
microglia activation
Online Access:https://www.mdpi.com/2227-9059/10/6/1346

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https://www.mdpi.com/2227-9059/10/6/1346

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