Comprehensive analysis of non-synonymous SNPs related to Parkinson’s disease and molecular dynamics simulation of PRKN mutants

Comprehensive analysis of non-synonymous SNPs related to Parkinson’s disease and molecular dynamics simulation of PRKN mutants

Parkinson’s disease (PD) is associated with a mutation in the PRKN (Parkin RBR E3 Ubiquitin Protein Ligase). PRKN functions as maintaining dopamine (DA) neuronal homeostasis and homeostasis dysfunction, which play an important role in early PD onset. The main objective behind this work is to identif...

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Bibliographic Details
Main Authors: Sapna Pandey, Neha Maurya, Himanshu Avashthi, Pramod Katara, Satendra Singh, Budhayash Gautam, Dev Bukhsh Singh
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Parkinson’s Disease PRKN
Non-synonymous SNPs
Molecular dynamic simulation
Annovar
Mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623000565

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http://www.sciencedirect.com/science/article/pii/S2211715623000565

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