Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Objective: Transport of Ca2+ into pancreatic β cell mitochondria facilitates nutrient-mediated insulin secretion. However, the underlying mechanism is unclear. Recent establishment of the molecular identity of the mitochondrial Ca2+ uniporter (MCU) and associated proteins allows modification of mito...

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Bibliographic Details
Main Authors: N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson, E. Cowan, H. Barnard, Y. Sancak, K.J. Kamer, P. Spégel, M. Fex, A. Tengholm, V.K. Mootha, D.G. Nicholls, H. Mulder
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Metabolism
Subjects:
Mitochondrial calcium uniporter
Voltage-dependent calcium channels
Bioenergetics
Knockout mice
Stimulus-secretion coupling
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000843

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http://www.sciencedirect.com/science/article/pii/S2212877821000843

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