A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan

A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan

Background: Native mass spectrometry (nMS) approaches appear attractive to complement bottom-up strategies traditionally used in biopharmaceutical industries thanks to their quite straightforward and rapid workflows, especially through online hyphenation of non-denaturing liquid chromatography (LC)...

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Bibliographic Details
Main Authors: Evolène Deslignière, Hélène Diemer, Stéphane Erb, Pierre Coliat, Xavier Pivot, Alexandre Detappe, Oscar Hernandez-Alba, Sarah Cianférani
Format: Article
Language:English
Published: IMR Press 2022-10-01
Series:Frontiers in Bioscience-Landmark
Subjects:
native mass spectrometry (ms)
liquid chromatography (lc)
size exclusion chromatography (sec)
cation exchange chromatography (cex)
hydrophobic interaction chromatography (hic)
higher order structures
biotherapeutics
antibody-drug conjugate (adc)
Online Access:https://www.imrpress.com/journal/FBL/27/10/10.31083/j.fbl2710290

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https://www.imrpress.com/journal/FBL/27/10/10.31083/j.fbl2710290

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