Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates

Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates

Conjugation of TP10, a cell-penetrating peptide with intrinsic antimalarial activity, to the well-known antimalarial drugs chloroquine and primaquine has been previously shown to enhance the peptide’s action against, respectively, blood- and liver-stage malaria parasites. Yet, this was achieved at t...

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Bibliographic Details
Main Authors: Luísa Aguiar, Marina Pinheiro, Ana Rute Neves, Nuno Vale, Sira Defaus, David Andreu, Salette Reis, Paula Gomes
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Membranes
Subjects:
antimalarial
biophysics
cell penetrating peptide
dynamic light scattering
haemolysis
lipid membranes
Online Access:https://www.mdpi.com/2077-0375/11/1/4

Internet

https://www.mdpi.com/2077-0375/11/1/4

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