State-Targeting Stabilization of Adenosine A<sub>2A</sub> Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein

State-Targeting Stabilization of Adenosine A<sub>2A</sub> Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein

G-protein coupled receptors (GPCRs) are known for their low stability and large conformational changes upon transitions between multiple states. A widely used method for stabilizing these receptors is to make chimeric receptors by fusing soluble proteins (i.e., fusion partner proteins) into the intr...

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Bibliographic Details
Main Authors: Masaya Mitsumoto, Kanna Sugaya, Kazuki Kazama, Ryosuke Nakano, Takahiro Kosugi, Takeshi Murata, Nobuyasu Koga
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
computational protein design
protein stabilization
de novo designed protein
fusion partner protein
G-protein coupled receptor
adenosine A<sub>2A</sub> receptor
Online Access:https://www.mdpi.com/1422-0067/22/23/12906

Internet

https://www.mdpi.com/1422-0067/22/23/12906

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