Inactivation influences the extent of inhibition of voltage-gated Ca+2 channels by Gem—implications for channelopathies

Inactivation influences the extent of inhibition of voltage-gated Ca+2 channels by Gem—implications for channelopathies

Voltage-gated Ca2+ channels (VGCC) directly control muscle contraction and neurotransmitter release, and slower processes such as cell differentiation, migration, and death. They are potently inhibited by RGK GTP-ases (Rem, Rem2, Rad, and Gem/Kir), which decrease Ca2+ channel membrane expression, as...

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Bibliographic Details
Main Authors: Salma Allam, Rose Levenson-Palmer, Zuleen Chia Chang, Sukhjinder Kaur, Bryan Cernuda, Ananya Raman, Audrey Booth, Scott Dobbins, Gabrielle Suppa, Jian Yang, Zafir Buraei
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Physiology
Subjects:
ataxia
Ca2+
channelopathy
GTPase
heart
ion channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1155976/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1155976/full

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