Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia

How object salience is encoded in the cortex and basal ganglia remains incompletely understood. Here, the authors show that individual prefrontal cortex neurons are jointly sensitive to the memory of value, aversiveness, novelty, and recency of objects, while the substantia nigra reticulata filters...

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Bibliographic Details
Main Authors: Ali Ghazizadeh, Okihide Hikosaka
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33514-3