Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates

Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates

Summary: Transactive response DNA-binding protein of 43 kDa (TDP-43) is a highly conserved, ubiquitously expressed nucleic acid-binding protein that regulates DNA/RNA metabolism. Genetics and neuropathology studies have linked TDP-43 to several neuromuscular and neurological disorders including amyo...

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Bibliographic Details
Main Authors: Baggio A. Evangelista, Shannon R. Cahalan, Joey V. Ragusa, Angie Mordant, Julie C. Necarsulmer, Robert J. Perna, Tejazaditya Ajit, Kristen White, Natalie K. Barker, Xu Tian, Sarah Cohen, Rick Meeker, Laura E. Herring, Todd J. Cohen
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Biological sciences
Biochemistry
Molecular biology
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007228

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223007228

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