High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells

High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells

Background/Aims: Hyperglycemia has been shown to increase the incidence and metastasis in various types of cancers. However, the correlation between hyperglycemia and lymphatic metastasis in prostate cancer (PCa) remains unclear. Our previous study demonstrated that lysophosphatidic acid (LPA) enhan...

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Bibliographic Details
Main Authors: Yuan-Li Huang, Yueh-Chien Lin, Chu-Cheng Lin, Wei-Min Chen, Benjamin P.C. Chen, Hsinyu Lee
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Vascular endothelial growth factor-C
Lysophosphatidic acid
Prostate cancer
Hyperglycemia
Lymphangiogenesis
Online Access:https://www.karger.com/Article/FullText/494177

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https://www.karger.com/Article/FullText/494177

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