Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the currently available antibiotics. This is particularly true for mycobacterial infections like tuberculosis and leprosy and those with emerging...

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Bibliographic Details
Main Authors: Sherine E. Thomas, William J. McCarthy, Jamal El Bakali, Karen P. Brown, So Yeon Kim, Michal Blaszczyk, Vítor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
Mycobacterium abscessus
Mycobacterium tuberculosis
Coenzyme A pathway
CoaD/ PPAT
drug discovery
fragment-based
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.880432/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.880432/full

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