HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway

HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway

Abstract Background The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of the mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and cell survival under hypoxic conditions. Because the liver has a naturally low o...

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Bibliographic Details
Main Authors: Kuiyuan Huang, Ziying Liu, Zhanglian Xie, Xiaoran Li, Haixing Zhang, Yu Chen, Yiran Wang, Zimo Lin, Chuanjiang Li, Hongyan Liu, Xiaoyong Zhang
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
HIGD2A
Mitochondria
ATP
The MAPK/ERK pathway
Online Access:https://doi.org/10.1186/s12967-023-04105-7

Internet

https://doi.org/10.1186/s12967-023-04105-7

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