Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2′,3′-dideoxyguanosine

Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2′,3′-dideoxyguanosine

Complement activation in the brain contributes to the pathology of neuroinflammatory and neurodegenerative diseases such as neuro-AIDS. Using semiquantitative in situ hybridization and immunohistochemistry, we observed an early and sustained increase in the expression of C1q, the initial recognition...

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Bibliographic Details
Main Authors: Candan Depboylu, Martin K.-H. Schäfer, Wilhelm J. Schwaeble, Todd A. Reinhart, Hitomi Maeda, Hiroaki Mitsuya, Ruslan Damadzic, Dianne M. Rausch, Lee E. Eiden, Eberhard Weihe
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neurobiology of Disease
Subjects:
Complement
Microglia
Neuro-AIDS
Antiretroviral treatment
Blood–brain barrier
Cell proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000410

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http://www.sciencedirect.com/science/article/pii/S0969996105000410

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