Exploring the Leukemogenic Potential of GATA-1<sub>S</sub>, the Shorter Isoform of GATA-1: Novel Insights into Mechanisms Hampering Respiratory Chain Complex II Activity and Limiting Oxidative Phosphorylation Efficiency

Exploring the Leukemogenic Potential of GATA-1<sub>S</sub>, the Shorter Isoform of GATA-1: Novel Insights into Mechanisms Hampering Respiratory Chain Complex II Activity and Limiting Oxidative Phosphorylation Efficiency

GATA-1 is a key regulator of hematopoiesis. A balanced ratio of its two isoforms, GATA-1<sub>FL</sub> and GATA-1<sub>S</sub>, contributes to normal hematopoiesis, whereas aberrant expression of GATA-1<sub>S</sub> alters the differentiation/proliferation potential...

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Bibliographic Details
Main Authors: Silvia Trombetti, Raffaele Sessa, Rosa Catapano, Laura Rinaldi, Alessandra Lo Bianco, Antonio Feliciello, Paola Izzo, Michela Grosso
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Antioxidants
Subjects:
myeloid leukemia
SDHC
respiratory chain complex II
GATA-1 isoforms
leukemogenesis
oxidative phosphorylation
Online Access:https://www.mdpi.com/2076-3921/10/10/1603

Internet

https://www.mdpi.com/2076-3921/10/10/1603

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