Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway

Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway

Abstract BRAF V600E-mutant colorectal cancer (CRC) is a rare subtype of colorectal cancer with poor prognosis. Compelling evidence indicates that the heparanase (HPSE) gene has multiple functions in cancer, however, its role in BRAF V600E-mutant CRC remains elusive. Differentially expressed genes be...

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Bibliographic Details
Main Authors: Mengling Liu, Xiaojing Xu, Ke Peng, Pengcong Hou, Yitao Yuan, Suyao Li, Xun Sun, Zhongyi Shi, Jiayu Zhang, Yu Dong, Qing Liu, Luoyan Ai, Li Liang, Lu Gan, Qihong Huang, Yiyi Yu, Tianshu Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00428-0

Internet

https://doi.org/10.1038/s41389-022-00428-0

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