Is Glial Dysfunction the Key Pathogenesis of <i>LRRK2</i>-Linked Parkinson’s Disease?
Leucine rich-repeat kinase 2 (<i>LRRK2</i>) is the most well-known etiologic gene for familial Parkinson’s disease (PD). Its gene product is a large kinase with multiple functional domains that phosphorylates a subset of Rab small GTPases. However, studies of autopsy cases with LRRK2 mut...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/1/178 |