Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis

Abstract Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes. Ribosome biogenesis is tightly coordinated with cell proliferation and its perturbation activates a...

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Bibliographic Details
Main Authors: Judith Dönig, Hannah Mende, Jimena Davila Gallesio, Kristina Wagner, Paul Hotz, Kathrin Schunck, Tanja Piller, Soraya Hölper, Sara Uhan, Manuel Kaulich, Matthias Wirth, Ulrich Keller, Georg Tascher, Katherine E. Bohnsack, Stefan Müller
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43751-9

Internet

https://doi.org/10.1038/s41467-023-43751-9

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