IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice

IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice

IntroductionCerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin-like growth factor 1 (IGF-1), a vasoprotective hormone, decrease during aging. Decreased circulating IGF-1 in animal model...

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Bibliographic Details
Main Authors: Lauren R. Miller, Marisa A. Bickel, Stefano Tarantini, Megan E. Runion, Zoe Matacchiera, Michaela L. Vance, Clara Hibbs, Hannah Vaden, Domonkos Nagykaldi, Teryn Martin, Elizabeth C. Bullen, Jessica Pinckard, Tamas Kiss, Eric W. Howard, Andriy Yabluchanskiy, Shannon M. Conley
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
insulin-like growth factor-1
intracerebral hemorrhage
microhemorrhage
brain
aging
cerebrovascular aging
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1320808/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1320808/full

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