Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans lead to neurolipofuscinosis (NCL) and is important in removi...

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Bibliographic Details
Main Authors: Xiaosen Ouyang, Willayat Y. Wani, Gloria A. Benavides, Matthew J. Redmann, Hai Vo, Thomas van Groen, Victor M. Darley-Usmar, Jianhua Zhang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Cathepsin D transgenic mouse
Mitochondrial bioenergetics
Apoptosis
Cathepsin D knockout mice
Dopamine
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002770

Internet

http://www.sciencedirect.com/science/article/pii/S2211383523002770

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