Transcriptional signatures of the BCL2 family for individualized acute myeloid leukaemia treatment

Abstract Background Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated regulatory networks make individualized therapy difficult. This study aimed to discover the transcriptional signat...

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Bibliographic Details
Main Authors: Chansub Lee, Sungyoung Lee, Eunchae Park, Junshik Hong, Dong-Yeop Shin, Ja Min Byun, Hongseok Yun, Youngil Koh, Sung-Soo Yoon
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13073-022-01115-w