Mitochondrial Proteome of Affected Glutamatergic Neurons in a Mouse Model of Leigh Syndrome

Mitochondrial Proteome of Affected Glutamatergic Neurons in a Mouse Model of Leigh Syndrome

Defects in mitochondrial function lead to severe neuromuscular orphan pathologies known as mitochondrial disease. Among them, Leigh Syndrome is the most common pediatric presentation, characterized by symmetrical brain lesions, hypotonia, motor and respiratory deficits, and premature death. Mitochon...

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Bibliographic Details
Main Authors: Alejandro Gella, Patricia Prada-Dacasa, Montserrat Carrascal, Andrea Urpi, Melania González-Torres, Joaquin Abian, Elisenda Sanz, Albert Quintana
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Leigh syndrome
animal models
neuroscience
proteomics
cell type-specific
mitochondrial isolation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00660/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00660/full

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