Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation

Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation

Hyperglycemia increases the heart sensitivity to ischemia-reperfusion (IR), but the underlying cellular mechanisms remain unclear. Mitochondrial dynamics (the processes that govern mitochondrial morphology and their interactions with other organelles, such as the reticulum), has emerged as a key fac...

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Bibliographic Details
Main Authors: Mathilde Dubois, Doria Boulghobra, Gilles Rochebloine, Florian Pallot, Marc Yehya, Isabelle Bornard, Sandrine Gayrard, Florence Coste, Guillaume Walther, Gregory Meyer, Jean-Charles Gaillard, Jean Armengaud, Béatrice Alpha-Bazin, Cyril Reboul
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Mitochondria
Calcium homeostasis
Hyperglycemia
Ischemia-reperfusion
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172400020X

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http://www.sciencedirect.com/science/article/pii/S221323172400020X

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