Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity

Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity

A series of 3,3-diethylazetidine-2,4-dione based thiazoles <b>3a</b>–<b>3j</b> were designed and synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The representative compounds <b>3c</b>, <b>3e</b>, and <b>3h</b&...

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Bibliographic Details
Main Authors: Beata Donarska, Marta Świtalska, Joanna Wietrzyk, Wojciech Płaziński, Magdalena Mizerska-Kowalska, Barbara Zdzisińska, Krzysztof Z. Łączkowski
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
human neutrophil elastase
antiproliferative activity
thiazole
molecular docking
Online Access:https://www.mdpi.com/1422-0067/23/14/7566

Internet

https://www.mdpi.com/1422-0067/23/14/7566

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