In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2R1441G mutant mouse model of Parkinson's disease

In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2R1441G mutant mouse model of Parkinson's disease

Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) mutation is a common genetic risk factor of Parkinson's disease (PD). Presynaptic dysfunction is an early pathogenic event associated with dopamine (DA) dysregulation in striatum of the brain. DA uptake activity of DA uptake transporter (...

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Bibliographic Details
Main Authors: Philip Wing‐Lok Ho, Lingfei Li, Hui‐Fang Liu, Zoe Yuen‐Kiu Choi, Eunice Eun Seo Chang, Shirley Yin‐Yu Pang, Yasine Malki, Chi‐Ting Leung, Michelle Hiu‐Wai Kung, David Boyer Ramsden, Shu‐Leong Ho
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Brain and Behavior
Subjects:
behavioral test
dopamine uptake
LRRK2 mutation
SYNGR3
Online Access:https://doi.org/10.1002/brb3.2886

Internet

https://doi.org/10.1002/brb3.2886

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