Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice
This study investigated the effects of galactose-depleted xyloglucan derived from tamarind seed gum (GXG-TG) on glucose and lipid metabolism in diet-induced obese mice by comparison with intact xyloglucan (TG). Twenty-four male C57BL/6J mice were fed a high-fat diet containing 3 g/100 g of either GX...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000288 |
| _version_ | 1797311565940129792 |
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| author | Seiichiro Aoe Michiko Kato Kazuhiko Yamatoya |
| author_facet | Seiichiro Aoe Michiko Kato Kazuhiko Yamatoya |
| author_sort | Seiichiro Aoe |
| collection | DOAJ |
| description | This study investigated the effects of galactose-depleted xyloglucan derived from tamarind seed gum (GXG-TG) on glucose and lipid metabolism in diet-induced obese mice by comparison with intact xyloglucan (TG). Twenty-four male C57BL/6J mice were fed a high-fat diet containing 3 g/100 g of either GXG-TG or TG for 12 weeks. Reduction of postprandial glucose rise was observed in the TG group compared to the control, whereas the GXG-TG group showed intermediate values. Serum cholesterol levels and hepatic mRNA expression of HMG-CoA reductase were significantly lower in the GXG-TG and TG groups compared to the control, while there was no increase in cecal short chain fatty acids in the GXG-TG or TG group. These results indicated that GXG-TG was converted to insoluble dietary fiber and maintained the serum cholesterol-lowering effect, although the blood glucose level-lowering effect was attenuated. TG, although moderately viscous, improved glucose tolerance and lipid metabolism in diet-induced obesity model mice. |
| first_indexed | 2024-03-08T02:02:04Z |
| format | Article |
| id | doaj.art-2eeb8e9fa3fc4e20bb2082aa877825aa |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T02:02:04Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2eeb8e9fa3fc4e20bb2082aa877825aa2024-02-14T05:14:31ZengElsevierJournal of Functional Foods1756-46462024-02-01113106026Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese miceSeiichiro Aoe0Michiko Kato1Kazuhiko Yamatoya2Department of Food Science, Otsuma Women’s University, Tokyo Japan; The Institute of Human Culture Studies, Otsuma Women’s University, Tokyo, Japan; Corresponding author at: Department of Food Science, Otsuma Women’s University, Tokyo Japan.The Institute of Human Culture Studies, Otsuma Women’s University, Tokyo, JapanShibata Gakuen University, Aomori, JapanThis study investigated the effects of galactose-depleted xyloglucan derived from tamarind seed gum (GXG-TG) on glucose and lipid metabolism in diet-induced obese mice by comparison with intact xyloglucan (TG). Twenty-four male C57BL/6J mice were fed a high-fat diet containing 3 g/100 g of either GXG-TG or TG for 12 weeks. Reduction of postprandial glucose rise was observed in the TG group compared to the control, whereas the GXG-TG group showed intermediate values. Serum cholesterol levels and hepatic mRNA expression of HMG-CoA reductase were significantly lower in the GXG-TG and TG groups compared to the control, while there was no increase in cecal short chain fatty acids in the GXG-TG or TG group. These results indicated that GXG-TG was converted to insoluble dietary fiber and maintained the serum cholesterol-lowering effect, although the blood glucose level-lowering effect was attenuated. TG, although moderately viscous, improved glucose tolerance and lipid metabolism in diet-induced obesity model mice.http://www.sciencedirect.com/science/article/pii/S1756464624000288Tamarind seed gumGalactose-depleted xyloglucanDiet-induced obese miceSerum cholesterolHMG-CoA reductaseGlucose tolerance |
| spellingShingle | Seiichiro Aoe Michiko Kato Kazuhiko Yamatoya Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice Journal of Functional Foods Tamarind seed gum Galactose-depleted xyloglucan Diet-induced obese mice Serum cholesterol HMG-CoA reductase Glucose tolerance |
| title | Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice |
| title_full | Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice |
| title_fullStr | Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice |
| title_full_unstemmed | Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice |
| title_short | Effect of galactose-depleted and intact xyloglucan intake on glucose and lipid metabolism in diet-induced obese mice |
| title_sort | effect of galactose depleted and intact xyloglucan intake on glucose and lipid metabolism in diet induced obese mice |
| topic | Tamarind seed gum Galactose-depleted xyloglucan Diet-induced obese mice Serum cholesterol HMG-CoA reductase Glucose tolerance |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000288 |
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