NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

BackgroundThiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression. The nudix hydrolase 15 (NUDT15) genetic polymorphism is strongly associated with the tolerance and myelosupp...

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Bibliographic Details
Main Authors: Fang Zhang, Gulbanur Amat, Yanjing Tang, Ru Chen, Xin Tian, Wenting Hu, Changcheng Chen, Shuhong Shen, Yangyang Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pediatrics
Subjects:
NUDT15 polymorphism
Uighur
Kirghiz
Dai
mercaptopurine
hematotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.832363/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2022.832363/full

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