Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage

Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage

Preclinical and clinical studies suggest that consumption of long chain omega-3 polyunsaturated fatty acids (PUFAs) reduces severity of chronic inflammatory and autoimmune diseases. While these ameliorative effects are conventionally associated with downregulated expression of proinflammatory cytoki...

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Bibliographic Details
Main Authors: Kathryn A. Wierenga, Frank M. Riemers, Bart Westendorp, Jack R. Harkema, James J. Pestka
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
inflammatory gene expression
omega-3 polyunsaturated fatty acids
cholesterol metabolism
TLR4 signaling
NF-κB
IFN signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.993614/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.993614/full

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