Ammonia Induces a Myostatin-Mediated Atrophy in Mammalian Myotubes, but Induces Hypertrophy in Avian Myotubes

Ammonia, a byproduct of protein catabolism that is generally regarded as toxic, is processed by the liver for excretion. In diseases resulting in hepatic insufficiency, circulating ammonia levels increase dramatically, ensuing secondary disorders. Sarcopenia, or loss of muscle mass, is commonly asso...

Full description

Bibliographic Details
Main Authors: Rachel A. Stern, Srinivasan Dasarathy, Paul E. Mozdziak
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Sustainable Food Systems
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fsufs.2019.00115/full