Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model

Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model

Abstract Background Establishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for developing new IVD therapies. The intra-articular injection of monosodium iodoacetate (MIA), which is commonly used in animal models of osteoarthritis, induces cartilage degeneration...

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Bibliographic Details
Main Authors: Takao Sudo, Koji Akeda, Koki Kawaguchi, Takahiro Hasegawa, Junichi Yamada, Nozomu Inoue, Koichi Masuda, Akihiro Sudo
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Arthritis Research & Therapy
Subjects:
Intervertebral disc
Disc degeneration
Monosodium iodoacetate
μCT
MRI
Histology
Online Access:https://doi.org/10.1186/s13075-021-02686-6

Internet

https://doi.org/10.1186/s13075-021-02686-6

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