Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction.

Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction.

Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiation of mitochondrial-mediated apoptosis are pathological responses to hypoxia-ischemia (HI) in the neonatal brain. Carnitine metabolism directly supports mitochondrial metabolism by shuttling long cha...

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Bibliographic Details
Main Authors: Thomas F Rau, Qing Lu, Shruti Sharma, Xutong Sun, Gregory Leary, Matthew L Beckman, Yali Hou, Mark S Wainwright, Michael Kavanaugh, David J Poulsen, Stephen M Black
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3439445?pdf=render

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http://europepmc.org/articles/PMC3439445?pdf=render

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