Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase

Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase

Induced pluripotent stem cell (iPSC)-based generation of tyrosine hydroxylase-positive (TH+) dopaminergic neurons (DNs) is a powerful method for creating patient-specific in vitro models to elucidate mechanisms underlying Parkinson’s disease (PD) at the cellular and molecular level and to perform dr...

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Bibliographic Details
Main Authors: Aleksandar Rakovic, Dorothea Voß, Franca Vulinovic, Britta Meier, Ann-Katrin Hellberg, Carla Nau, Christine Klein, Enrico Leipold
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dopaminergic neurons
tyrosine hydroxylase
differentiation
Parkinson’s disease
patch-clamp
electrophysiology
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.817198/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.817198/full

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