B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer

B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer

Abstract Negative immune checkpoint blockade immunotherapy has shown potential for multiple malignancies including colorectal cancer (CRC). B7-H5, a novel negative immune checkpoint regulator, is highly expressed in tumor tissues and promotes tumor immune escape. However, the clinical significance o...

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Bibliographic Details
Main Authors: Jiayu Wang, Hongya Wu, Yanjun Chen, Jinghan Zhu, Linqing Sun, Juntao Li, Zhendong Yao, Yuqi Chen, Xueguang Zhang, Suhua Xia, Weichang Chen, Tongguo Shi
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00628-4

Internet

https://doi.org/10.1038/s41420-021-00628-4

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