Development of synergistic antifungal in situ gel of miconazole nitrate loaded microemulsion as a novel approach to treat vaginal candidiasis

Development of synergistic antifungal in situ gel of miconazole nitrate loaded microemulsion as a novel approach to treat vaginal candidiasis

Abstract Limited solubility is the main cause of the low local availability of anti-candidiasis drug, miconazole nitrate (MN). The study’s objective was to develop and characterize microemulsion (ME) based temperature-triggered in situ gel of MN for intravaginal administration to enhance local avail...

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Bibliographic Details
Main Authors: Omar M. Alwan, Iman S. Jaafar
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Miconazole nitrate
Microemulsion
Essential oil
Antifungal action
Solubility enhancement
In situ gel
Online Access:https://doi.org/10.1038/s41598-024-74021-3

Internet

https://doi.org/10.1038/s41598-024-74021-3

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