Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target

Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target

Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly mitofusins mediate fusion of the outer membrane is still unclear. Structural studies enable tailored design of mitofusi...

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Bibliographic Details
Main Authors: Ira Buntenbroich, Vincent Anton, Daniel Perez-Hernandez, Tânia Simões, Felix Gaedke, Astrid Schauss, Gunnar Dittmar, Jan Riemer, Mafalda Escobar-Henriques
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Biological sciences
Genetics
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422301091X

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http://www.sciencedirect.com/science/article/pii/S258900422301091X

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