<i>ALK</i>, <i>ROS1</i>, <i>RET</i> and <i>NTRK1–3</i> Gene Fusions in Colorectal and Non-Colorectal Microsatellite-Unstable Cancers

<i>ALK</i>, <i>ROS1</i>, <i>RET</i> and <i>NTRK1–3</i> Gene Fusions in Colorectal and Non-Colorectal Microsatellite-Unstable Cancers

This study aimed to conduct a comprehensive analysis of actionable gene rearrangements in tumors with microsatellite instability (MSI). The detection of translocations involved tests for 5′/3′-end expression imbalance, variant-specific PCR and RNA-based next generation sequencing (NGS). Gene fusions...

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Bibliographic Details
Main Authors: Rimma S. Mulkidjan, Evgeniya S. Saitova, Elena V. Preobrazhenskaya, Karimat A. Asadulaeva, Mikhail G. Bubnov, Ekaterina A. Otradnova, Darya M. Terina, Sofia S. Shulga, Darya E. Martynenko, Maria V. Semina, Evgeniya V. Belogubova, Vladislav I. Tiurin, Priscilla S. Amankwah, Aleksandr S. Martianov, Evgeny N. Imyanitov
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
microsatellite instability
gene rearrangements
PCR
NGS
colorectal cancer
unbalanced expression
Online Access:https://www.mdpi.com/1422-0067/24/17/13610

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https://www.mdpi.com/1422-0067/24/17/13610

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