Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction

Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction

Background It remains unclear whether abnormal systolic function and relaxation are essential for developing heart failure in pathophysiology of severe aortic stenosis. Methods and Results Yorkshire pigs underwent surgical banding of the ascending aorta. The animals were followed for up to 5 months...

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Bibliographic Details
Main Authors: Kiyotake Ishikawa, Jaume Aguero, Jae Gyun Oh, Nadjib Hammoudi, Lauren A. Fish, Lauren Leonardson, Belén Picatoste, Carlos G. Santos‐Gallego, Kenneth M. Fish, Roger J. Hajjar
Format: Article
Language:English
Published: Wiley 2015-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
diastolic dysfunction
fibrosis
hypertrophy
stiffness
systolic dysfunction
Online Access:https://doi.org/10.1161/JAHA.115.001925

Internet

https://doi.org/10.1161/JAHA.115.001925

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