P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegenerationResearch in context

P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegenerationResearch in context

Summary: Background: Recent studies suggesting the importance of the gut-microbiome in intestinal aggregated alpha synuclein (α-syn) have led to the exploration of the possible role of the gut-brain axis in central nervous system degeneration. Proteus mirabilis (P. mirabilis), a gram-negative facul...

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Bibliographic Details
Main Authors: Eugene Huh, Jin Gyu Choi, Yujin Choi, In Gyoung Ju, Bora Kim, Yoon-Jung Shin, Jong Min An, Myoung Gyu Park, Sung Vin Yim, Su Jin Chung, Sang-Uk Seo, Dokyoung Kim, Chun Hyung Kim, Dong Hyun Kim, Myung Sook Oh
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:EBioMedicine
Subjects:
Microbiota-gut-brain axis
Neurodegenerative disease
Alpha-synuclein
Proteus mirabilis
Haemolysin A
Pore formation
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300453X

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http://www.sciencedirect.com/science/article/pii/S235239642300453X

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